University of Strasbourg
The public research institute INSERM (French National Institute of Health and Medical Research) located at the University of Strasbourg (UDS) operates under the joint authority of the French Ministry of Health and the French Ministry of Research.
The "Biomaterials and Bioengineering" Unit UMR-1121 is involved in IMMODGEL and aims at developing new functionalized biomaterials, This lab focuses on both fundamental aspects of materials for health such as mechanotransduction and more applied issues illustrated by the development of innovative theranostic nanoparticles, dental and laryngo-tracheal implants and personalized biomaterials. Some biomimetic approaches are also developed to design functional materials, for example by using antimicrobial peptides originates from human body to confer antibacterial and antifungal properties on biomaterial surfaces. Moreover, mussel-inspired adhesive coatings based on melanin and catecholamine constitute a new research focus of the lab.
The staff of the unit is currently composed of 45 people. The lab was involved in many collaborative research networks over the last five years, including eight grants from the French National Research Agency and one European project. The INSERM UMR-1121 lab has published more than 130 papers in high ranking journals since 2007 and has applied for 12 patents, some of them with IMMODGEL´s scientific coordinator Protip.
Role in IMMODGEL
UDS addresses all research aspects ranging from material engineering, in-vitro and in-vivo characterization, to clinical application. A multidisciplinary team involving physicists, chemists, physico-chemists, molecular and cell biologists and clinicians contributes to the project.
UDS will design the polyelectrolyte multilayer based system with cytokine release capacity and different attachment modalities, which will also attach the immunomodulatory gel to the model implant. Moreover, the main objective of UDS is to prove the effectiveness of the developed IMMODGEL system in terms of positive remodeling effects and sustainability under in vivo conditions.
UDS is furthermore in charge of demonstrating the predictive capabilities of the foreign body response on a chip and multiplex diagnostic test systems.