Protobios LLC (PTB) is a private Estonian biotech company established in 2003. With offices and research laboratories located in the campus of Tallinn University of Technology and Tallinn Science Park, the SME specialises in molecular diagnostics. It develops innovative technologies in the field of immunology, providing research and diagnostics services for companies and hospitals worldwide.
Since 2009, PTB has focused on biomarker discovery. Its laboratory - accredited with an ISO 17025 certificate- offers a comprehensive allergen detection service to the food industry.
With support from Enterprise Estonia, PTB is a founding member of the biomedical initiatives Medicine Estonia, the Estonian Cell Therapy Cluster, the Estonian HealthTech Cluster and the Competence Centre for Cancer Research.
Role in IMMODGEL
Applying its experience in a broad spectrum of biological analysis methods - ranging from cell assays to genetic and immunogenicity studies – PTB is in charge of identifying the effects of the encapsulation conditions on macrophage phenotype with different gel constituents and physical properties. It is also responsible for analysing the degradation kinetics of the gels by these cells to determine the actual duration of immunomodulation.
A further task consists in establishing the optimal specific cytokine conditions to obtain the desired macrophage phenotype within the system. Moreover, PTB takes over the development of cytokine analysis tests that will serve to optimise and re-adjust the cytokine release within the hydrogel in the presence of macrophages.